Muscular System on the MCAT

Woman lifting weights to illustrate muscular system MCAT - image by Magoosh

A big part of scoring well on the Biological and Biochemical Foundations of Living Systems section is familiarizing yourself with muscular system MCAT content. Below, we’ll go over some key facts about skeletal muscles, smooth muscle contraction, and more.

For a super handy PDF version of this material, and for more MCAT resources, click the link below!

Click here to download more Magoosh MCAT resources

Organization of Skeletal Muscles

First and foremost, here’s a simple breakdown of how skeletal muscle is organized:

Click here for Magoosh's free MCAT practice test

Muscular system MCAT breakdown - image by Magoosh

You’ll also need to understand the difference between smooth muscle and skeletal muscle, which we’ve broken down for you here:

FunctionContraction Appearance
Smooth MuscleSurround organs (except for the heart) and blood vesselsInvoluntaryNonstriated or tapered
Skeletal MuscleMoves the skeleton VoluntaryStriated, multinucleated

Sarcomere MCAT Structure and the Sliding Filament Model

Understanding how muscles actually work is also key to success on the MCAT. Muscle contraction occurs when the motor protein, myosin, pulls on actin. The filaments move past one another, shortening the sarcomere and generating muscle tension.

For reference, sarcomere is the smallest functional unit of muscle, visible as striations on muscle cells.

The sliding filament model, as seen below, is used to represent this function in the muscular system. MCAT questions may pertain to any of the follow aspects of muscle contraction:

Sliding filament model - image by Magoosh

Muscle Components

To better understand the above model, it helps to know the various components of muscle and how they help facilitate contraction:

ComponentDefinition Effect on Contraction
Thick filamentComposed of myosinMyosin heads bind to actin
Thin filamentComposed of actinSlides past myosin
Z-LineMark the borders of the sarcomere. Site of connection for actin.Moves closer together
M-lineMidline of the sarcomereNo change
I BandContains only thin filamentsShortens
H BandContains only thick filamentsShortens
A BandThe length of the thick filamentsNo change

And when trying to memorize the functions of each of the above muscle components, here is one of our favorite memorization tips:

  • “The letter H is thicker than I”
    H Band = Thick filament
    I Band = Thin filament

    “HI is short for Hello”
    H and band I shorten in contraction

A Final Word on Muscular System MCAT Questions

Scoring well on the Biological and Biochemical Foundations of Living Systems section of the MCAT requires knowledge about the muscular system. Specifically, you’ll want a deep understanding of the interrelated parts and how they come together to create contraction and movement.

Click here for Magoosh's free MCAT practice test

For more MCAT practice, check out Magoosh’s MCAT prep, which includes 380 lessons, 745+ practice questions, personalized email assistance, and more!

Happy studying and good luck!

Get a free MCAT practice test!


  • Kat Thomson

    Kat is the Senior Curriculum Manager at Magoosh with a specialty in the MCAT. She has a BA from the University of California, Santa Barbara, and a Ph.D. in medical sociology from the University of California, San Francisco, where she earned the Distinguished Dissertation Award in the Social and Behavioral Sciences. Kat has been teaching premed and nursing students since 2005 as a Visiting Assistant Professor at the University of San Francisco, Bowdoin, and the University of California, Berkeley, while collaborating on multiple research projects and publications. In addition to the MCAT, Kat has taught courses in Research Methods, Gender, Global and Environmental Health, and others. She is passionate about increasing the number of underrepresented minorities in medicine and helping students get into the medical schools of their dreams. You can join Kat on Instagram and YouTube.

More from Magoosh

No comments yet.

Magoosh blog comment policy: To create the best experience for our readers, we will only approve comments that are relevant to the article, general enough to be helpful to other students, concise, and well-written! 😄 Due to the high volume of comments across all of our blogs, we cannot promise that all comments will receive responses from our instructors.

We highly encourage students to help each other out and respond to other students' comments if you can!

If you are a Premium Magoosh student and would like more personalized service from our instructors, you can use the Help tab on the Magoosh dashboard. Thanks!

Leave a Reply